Multi-drug Resistant Citrobacter freundii Isolates in a Burn Hospital in Northeast of Iran: A Single-Center Cross-sectional Study

Authors

  • Bahman Mirzaei Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science. Department of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Science
  • Ebrahim Shafaie Infectious diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
  • Hamid Reza Goli Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science.
  • Mohammad Reza Haghshenas Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science.
  • Zahra Norouzi Bazgir Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science. MSc Student Medical Microbiology and Virology,Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari Iran
Abstract:

Background: Multi-drug resistant (MDR) Citrobacter freundii (C. freundii) as a causative agent of nosocomial infections is a health threat, especially in hospitals. This study was conducted to determine the prevalence of MDR C. freundii, considering isolation sites and a variety of utilized antibiotics. Materials and Methods: In this cross-sectional study, the clinical samples of C. freundii strains were collected and screened using traditional bacteriological tests in Zareh Hospital, Sari City, Iran, during 2016-2017. We used disk diffusion methods to assess the susceptibility patterns of isolates according to the Clinical Laboratory Standard Institute (CLSI) guidelines. Results: Out of 3248 clinical samples, C. freundii strains were detected in 109 samples (32.1% females and 67.9% males). Susceptibility tests indicated that 89 isolates (81.65%) were MDR strains. Frequencies of MDR C. freundii strains were higher in the Behavioral Intensive Care Unit (BICU) (37.61%) and restoration ward (29.35%) compared with other hospital wards. Conclusion: Considering the MDR C. freundii strains detected from burn hospital wards, it is necessary to implement prevention criteria for their eradication from burn hospitals. The results indicate the urgent need to design more practical methods for controlling infection in hospital wards.

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Journal title

volume 8  issue 2

pages  63- 70

publication date 2020-05

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